Pioglitazone increases non-esterified fatty acid clearance in upper body obesity
نویسندگان
چکیده
منابع مشابه
Relations between plasma non-esterified fatty acid metabolism and body fat mobilization in primiparous lactating goats.
During early lactation ruminants can mobilize considerable amounts of body fat to maintain milk production. The aim of the present study was to evaluate the efficacy of tritiated water (TOH) and non-esterified fatty acid (NEFA) kinetics as means of monitoring adipose tissue fat mobilization in lactating goats. Body fat, as estimated by a two-pool model of TOH kinetics, and NEFA entry rate were ...
متن کاملNon-esterified fatty acid and glycerol kinetics and fatty acid re-esterification in goats during early lactation.
Non-esterified fatty acid (NEFA) and glycerol kinetics were studied in lactating goats to gain insight into the mechanisms by which animals in early lactation can initially mobilize and later replenish body fat reserves. Kinetic measurements were made at days 10, 38 and 76 post-partum in ten multiparous lactating does. Plasma NEFA concentrations and NEFA entry rate decreased as lactation advanc...
متن کاملFatty Acid Profile of CE in HSV - I - infected Human Arterial SMC Fatty acid esterified
Herpesviruses have been implicated as etiologic factors in the pathogenesis of human arteriosclerosis. We have examined the pathobiological effects of human herpes simplex virus (HSV-1) infection in influencing lipid accumulation and metabolism in human and bovine arterial smooth muscle cells (SMC). Significantly greater amounts of saturated cholesteryl esters (CE) and triacylglycerols (TG) acc...
متن کاملTurnover modeling of non-esterified fatty acids in rats after multiple intravenous infusions of nicotinic acid.
The objective of this investigation was to use a pharmacokinetic (PK)/pharmacodynamic (PD) approach to describe and evaluate a PK model of nicotinic acid (NiAc) in guinea pigs and a PD feedback model of changes in non-esterified fatty acid (NEFA) concentrations in rats following multiple intravenous infusions of NiAc at different rates and durations of inhouse and literature (NEFA after extrava...
متن کاملRegulation of the plasma non-esterified fatty acid concentration in the postprandial state.
NEFA, also known as free fatty acids (FFA), are the form in which stored body fat is transported from adipose tissue to its sites of utilization (Fig. 1). Their importance was recognized in the 1950s once methods became available for their reliable measurement in plasma. Because of the rapid turnover of plasma NEFA, they constitute a large proportion of the ‘energy flux’ through the bloodstream...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2005
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-005-0051-0